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Nonalcoholic Fatty Liver Disease
One of my favorites is the LIRKO mouse, or liver-specific insulin receptor knockout mouse. The LIRKO mouse is missing its insulin receptor in the liver only, so it is a model of severe insulin resistance of the liver. ...
Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From ...
OBJECTIVE—Insulin resistance in skeletal muscle plays a critical role in the pathogenesis of type 2 diabetes, yet the cellular mechanisms responsible for insulin resistance are poorly understood. In this study, we examine the role of ...
Posted in Insulin Resistance on September 28, 2008
Original article: Nonalcoholic Fatty Liver Disease
Tags: insulin, liver, resistance, mouse, receptor
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